Personalized medicine through three-dimensional cell-based culture systems in assisted reproductive technologies: How close are we?

      A microphysiological model system could offer key opportunities to advance the study of human embryo implantation and placentation. Such models would surmount ethical issues relating to human research as well as technical challenges for in vivo study. In addition, microphysiological models would enable the development of efficacious interventions in relevant biologic systems rather than in a “black box” model organism.
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        • Galan A.
        • Diaz-Gimeno P.
        • Poo M.E.
        • Valbuena D.
        • Sanchez E.
        • Ruiz V.
        • et al.
        Defining the genomic signature of totipotency and pluripotency during early human development.
        PLoS ONE. 2013; 8e62135
        • Yue C.
        • Chen A.C.H.
        • Tian S.
        • Fong S.W.
        • Lee K.C.
        • Zhang J.
        • et al.
        Human embryonic stem cell–derived blastocyst-like spheroids resemble human trophectoderm during early implantation process.
        Fertil Steril. 2020; 114: 653-664
        • Lalitkumar P.G.L.
        • Lalitkumar S.
        • Meng C.X.
        • Stavreus-Evers A.
        • Hambiliki F.
        • Bentin-Ley U.
        • et al.
        Mifepristone, but not levonorgestrel, inhibits human blastocyst attachment to an in vitro endometrial three-dimensional cell culture model.
        Hum Reprod. 2007; 22: 3031-3037
        • Turco M.Y.
        • Gardner L.
        • Hughes J.
        • Cindrova-Davies T.
        • Gomez M.J.
        • Farrell L.
        • et al.
        Long-term, hormone-responsive organoid cultures of human endometrium in a chemically defined medium.
        Nat Cell Biol. 2017; 19: 568-577
      1. Campo H, Murphy A, Yildiz S, Woodruff T, Cervelló I, Kim JJ. Microphysiological modeling of the human endometrium. Tissue Eng Part A. Epub 2020 April 28.

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