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Intergenerational programming and in vitro fertilization: another turn of the screw

      During human development, genome-wide epigenetic reprogramming occurs during gametogenesis and early embryo development, with epigenetic remodeling in somatic tissues continuing throughout prenatal development and into postnatal life. Based on the developmental origins of adult disease, these epigenetic events may be influenced by assisted reproductive technology (ART), which could alter embryonic and/or fetal growth trajectory to cause permanent physiological changes in offspring, thereby increasing the risk for cardiovascular disease in adulthood.
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