Intergenerational programming and in vitro fertilization: another turn of the screw

      During human development, genome-wide epigenetic reprogramming occurs during gametogenesis and early embryo development, with epigenetic remodeling in somatic tissues continuing throughout prenatal development and into postnatal life. Based on the developmental origins of adult disease, these epigenetic events may be influenced by assisted reproductive technology (ART), which could alter embryonic and/or fetal growth trajectory to cause permanent physiological changes in offspring, thereby increasing the risk for cardiovascular disease in adulthood.
      To read this article in full you will need to make a payment


        • Turner S.
        • Maclean E.
        • Dick S.
        • Aucott L.
        • Maheshwari A.
        Is conception by in vitro fertilization associated with altered antenatal and postnatal growth trajectories?.
        Fertil Steril. 2020; 114: 1214-1222
        • Litsky J.F.
        • Deyssenroth M.A.
        • Everson T.M.
        • Armstrong D.A.
        • Lambertini L.
        • Chen J.
        • et al.
        Placental imprinting variation associated with assisted reproductive technologies and subfertility.
        Epigenetics. 2017; 12: 653-661
        • Song S.
        • Ghosh J.
        • Mainigi M.
        • Turan N.
        • Weineman R.
        • Truongcao M.
        • et al.
        DNA methylation differences between in vitro- and in vivo-conceived children are associated with ART procedures rather than infertility.
        Clin Epigenetics. 2015; 7: 41-51
        • Choux C.
        • Binquest C.
        • Carmignac V.
        • Bruno C.
        • Chapusot C.
        • Barberet J.
        • et al.
        The epigenetic control of transposable elements and imprinted genes in newborns is affected by mode of conception: ART versus spontaneous conception without underlying infertility.
        Hum Reprod. 2018; 33: 331-340
        • Novakovic B.
        • Lewis S.
        • Halliday J.
        • Kennedy J.
        • Burgner D.P.
        • Czajko A.
        • et al.
        Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood.
        Nat Commun. 2019; 10: 3922

      Linked Article