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Neonatal outcomes in women with polycystic ovary syndrome after frozen-thawed embryo transfer

  • Jiaying Lin
    Affiliations
    Department of Assisted Reproduction, Shanghai Ninth People’s Hospital Affiliated to JiaoTong University School of Medicine, Shanghai, People’s Republic of China
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  • Haiyan Guo
    Affiliations
    Department of Assisted Reproduction, Shanghai Ninth People’s Hospital Affiliated to JiaoTong University School of Medicine, Shanghai, People’s Republic of China
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  • Bian Wang
    Affiliations
    Department of Assisted Reproduction, Shanghai Ninth People’s Hospital Affiliated to JiaoTong University School of Medicine, Shanghai, People’s Republic of China
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  • Qiuju Chen
    Affiliations
    Department of Assisted Reproduction, Shanghai Ninth People’s Hospital Affiliated to JiaoTong University School of Medicine, Shanghai, People’s Republic of China
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  • Qianqian Zhu
    Correspondence
    Reprint requests: Qianqian Zhu, Department of Assisted Reproduction, Shanghai Ninth People’s Hospital Affiliated to JiaoTong University School of Medicine, Zhizaoju Road No. 639, Shanghai, PR China.
    Affiliations
    Department of Assisted Reproduction, Shanghai Ninth People’s Hospital Affiliated to JiaoTong University School of Medicine, Shanghai, People’s Republic of China
    Search for articles by this author

      Objective

      To compare the risk of adverse neonatal outcomes after frozen embryo transfer (FET) among women with polycystic ovary syndrome (PCOS) with those among women without PCOS.

      Design

      Retrospective cohort study.

      Setting

      Tertiary-care academic medical center.

      Patient(s)

      In this study, we included 1,167 singletons born to mothers with PCOS and 9,995 singletons born to mothers without PCOS after FET during the period from January 1, 2007, to December 31, 2019.

      Intervention(s)

      None.

      Main Outcomes Measure(s)

      Adverse neonatal outcomes including preterm birth, low birth weight, high birth weight, small for gestational age (SGA), and large for gestational age.

      Result(s)

      The odds of preterm birth were significantly higher among infants from mothers with PCOS compared with those from mothers without PCOS. The odds of low birth weight and SGA were lower in mothers with PCOS compared with mothers without PCOS in the overall analysis, but the differences in low birth weight and SGA between mothers with and without PCOS did not exist in the subgroup analysis with a normal BMI population.

      Conclusion(s)

      The diagnosis of PCOS was independently associated with increased odds of preterm birth among women with singleton pregnancies by FET. In addition, decreased odds of low birth weight and SGA were observed among patients with PCOS, but the increased odds were not observed in the subset analysis of patients with PCOS with normal BMI.
      Resultados neonatales en mujeres con síndrome de ovario poliquístico después de transferencia de embriones criopreservados.

      Objetivo

      Comparar el riesgo de resultados neonatales adversos después de transferencia de embriones congelados (FET) en mujeres con síndrome de ovario poliquístico (PCOS) con los de mujeres sin PCOS.

      Diseño

      Estudio retrospectivo de cohortes.

      Entorno

      Centro médico académico de atención terciaria.

      Paciente(s)

      En este estudio, incluimos 1,167 recién nacidos únicos de madres con PCOS y 9,995 recién nacidos únicos de madres sin PCOS tras realizar FET durante el período 1 de enero de 2007 hasta el 31 de diciembre de 2019.

      Intervención(es)

      Ninguna.

      Resultado(s) principal(es)

      Resultados neonatales adversos incluyendo parto pretérmino, bajo peso al nacer, peso elevado al nacer, pequeño para la edad gestacional (SGA) y grande para la edad gestacional.

      Resultado(s)

      El riesgo de parto pretérmino fue significativamente mayor entre los nacidos de madres con PCOS comparados con aquellos nacidos de madres sin PCOS. El riesgo de bajo peso al nacer y SGA fueron inferiores en madres con PCOS comparado con madres son PCOS en el análisis global, pero las diferencias en bajo peso al nacer y SGA entre madres con y sin PCOS no existían en el análisis del subgrupo de población con BMI normal.

      Conclusión(es)

      El diagnóstico de PCOS se asoció de manera independiente con un aumento de riesgo de parto pretérmino entre las mujeres con embarazos únicos logrados con FET. Además, se observó una disminución del riesgo de bajo peso al nacer y SGA entre las pacientes con POS, pero el aumento de riesgo no se observó en el análisis del subgrupo de pacientes con PCOS y BMI normal.

      Key Words

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