Recurrent pregnancy losses, a lasting cause of infertility

      Recurrent pregnancy loss (RPL), defined as two to three spontaneous pregnancy terminations occurring before 12 weeks of gestation, affects approximately 1% of the general population. The causes may include congenital factors that originate with the quality of the gametes (sperm or oocyte) or the resulting embryo, or factors that originate within the uterus. Alterations of endometrial receptivity from endometriosis and/or endometritis, which are associated with impaired action of progesterone, have also been implicated in RPL. Finally, immunologic factors and thrombophilia, congenital and acquired, have also been suspected to cause RPL.

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        • Klimczak A.M.
        • Patel D.P.
        • Hotaling J.M.
        • Scott Jr., R.T.
        Role of the sperm, oocyte, and embryo in recurrent pregnancy loss.
        Fertil Steril. 2021; 115: 533-537
        • Carbonnel M.
        • Pirtea P.
        • de Ziegler D.
        • Ayoubi J.M.
        Uterine factors in recurrent pregnancy losses.
        Fertil Steril. 2021; 115: 538-545
        • Pirtea P.
        • Cicinelli E.
        • De Nola R.
        • de Ziegler D.
        • Ayoubi J.M.
        Endometrial causes to KPL: endometriosis, adenomyosis and chronic endometritis.
        Fertil Steril. 2021; 115: 546-560
        • Alecsandru D.
        • Klimczak A.M.
        • Garcia Velasco J.A.
        • Pirtea P.
        • Franasiak J.M.
        Immunological causes and thrombophilia in recurrent pregnancy losses (RPL).
        Fertil Steril. 2021; 115: 561-566