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Noninvasive preimplantation genetic testing for aneuploidy in spent blastocyst media will substitute for trophectoderm biopsy

  • Carlos Simon
    Affiliations
    Department of Obstetrics and Gynecology, Valencia University and Instituto de Investigación Sanitaria Hospital Clinico de Valencia, Valencia, Spain
    Department of Obstetrics and Gynecology, BIDMC Harvard University, Boston, Massachusetts
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      The discovery of cell-free fetal deoxyribonucleic acid in maternal plasma has enabled a paradigm shift in prenatal testing (
      • Lo Y.D.
      • Corbetta N.
      • Chamberlain P.F.
      • Rai V.
      • Sargent I.L.
      • Redman C.W.
      • et al.
      Presence of fetal DNA in maternal plasma and serum.
      ). Since its inception, noninvasive prenatal testing (niPGT) has dramatically changed clinical practice in prenatal care, allowing safer and earlier detection of genetic conditions of the fetus during the first trimester of pregnancy (
      • Bianchi D.W.
      • Parker R.L.
      • Wentworth J.
      • Madankumar R.
      • Saffer C.
      • Das A.F.
      • et al.
      DNA sequencing versus standard prenatal aneuploidy screening.
      ).
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      References

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